Dermatology Times 2024 In Review: Vitiligo

Reliable Correlation Explored Between RCM and Wood’s Lamp Assessment in Vitiligo, Study Details

Researchers analyzed the characteristics of Wood's lamp and reflective confocal laser scanning microcopy in guiding vitiligo staging.

Lower Quality of Life, Higher Levels of Anxiety and Depression Noted in Patients with Alopecia Versus Vitiligo

Researchers compared the quality of life, anxiety, depression, sleep disturbance, and other associated factors between patients with alopecia areata and vitiligo.

Positive Biomarker Data Shared Following Phase 1b Trial of VYN201 in Vitiligo

Researchers said this data is demonstrative of VYN201's positive effects on multiple vitiligo-related biomarkers.

First Known Canadian Study Evaluates Real-World Experiences of Patients With Vitiligo in Community Setting

Researchers noted that this study's findings are consistent with prior epidemiologic data.

Addition of Niosomal Atorvastatin 1% Ointment to Therapy With Topical Calcineurin Inhibitor Yields No Additional Effect in Non-Segmental Vitiligo

The combination therapy did not yield any effect in patients with non-segmental vitiligo and prompts additional large studies prior to conclusive efficacy.

Case Report: Repigmentation of the Lips Using Ruxolitinib

Dive into a complex case report of a 29-year-old African American male patient with Fitzpatrick skin type V with a 6-month reported history of vitiligo on his lips.

Late-Breaking Data: Upadacitinib for Vitiligo Achieves Skin Repigmentation Through Week 52

Iltefat Hamzavi, MD, reviews late-breaking data at AAD on upadacitinib as monotherapy.

Dietary Interventions May Serve as Worthwhile Adjunct Therapy in Patients With Vitiligo

While additional, larger studies are necessary, researchers said dietary choices may help reduce dependency on pharmacological methods.

Experts Develop Evidence and Consensus-Based Recommendations for Diagnosing and Treating Vitiligo in Young Patients

The recommendations were recently published in JAMA Dermatology following an extensive literature review, article grading, and a review of research questions.

Sexually Dimorphic Inflammatory Responses Key to Understanding Vitiligo, Study Finds

The study uncovered sexual dimorphism in melanocyte stem cell migration rates due to UVB-induced inflammatory responses in mice.

Patients With Vitiligo Show Lower Pulmonary Embolism and Peripheral Vascular Disease Risk, but Mortality Rises with Comorbidities

A recent study aimed to investigate the risk of myocardial infarction, cerebrovascular accident, peripheral vascular disease, and pulmonary embolism in patients with vitiligo.

Microneedling With and Without N-acetylcysteine Prove Effective in Patients With Persistent Vitiligo

While the addition of NAC yielded greater improvement than microneedling alone, this difference was not significant.

JAK Inhibitors Show Favorable Risk-Benefit Profile In Vitiligo, Especially for Facial Cases

A new review highlighted JAK inhibitors' role in vitiligo treatment, emphasizing varying benefits, facial efficacy, and potential for sustained responses.

Topical Antibiotic Treatment Significantly Reduced Depigmentation in Mouse Model

Topical Bacitracin, Neosporin, and Vaseline were applied to mice over a 6-week period.

VYNE Therapeutics Provides Updates on VYN201 for Nonsegmental Vitiligo and VYN202 for Inflammatory Diseases

VYNE expects to enroll the first patient with vitiligo in the phase 2b trial for VYN201 in the second quarter of 2024.

New Study Defines Severity Strata for Vitiligo Using Validated Physician Global Assessment Scores

These findings may provide guidance for future international definitions of degrees of activity and repigmentation in vitiligo.

Serum CXCL10 Levels Decreased With Use of Ruxolitinib Cream In Patients With Vitiligo

Data from the TRuE-V mechanism of action study was presented in a poster at the 2024 RAVE Conference.

Study Investigates Ties Between Vitiligo and Parkinson’s Disease

The study found patients with vitiligo are at a lower risk of developing PD, but those with comorbid PD could face elevated mortality rates.

Phase 3 Ruxolitinib Study Shows Higher Rates of Adolescent Repigmentation

David Rosmarin, MD, shared his insights on the study in a Q&A with Dermatology Times.

Vitiligo Leads to Heightened Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus, According to Mendelian Randomization

Researchers said individuals with vitiligo should monitor for RA and SLE, as regular check-ups are essential for managing this risk.

Type 1 Diabetes is a Risk Factor for Vitiligo Development, Study Reports

Researchers examined the role of diabetes and glycemic profile in the risk of development of vitiligo in a Mendelian randomization study.

Relationship Between Vitiligo and Psoriasis May Be Due, In Part, to Immunity

Skin with vitiligo and psoriasis shows increased immune cell type, with a Mendelian analysis finding no causal link between the conditions.

Vitiligo Risk Alleles Vary Across Different Populations, According to Study

The findings highlight the need for diverse genetic studies to understand their broader impact on autoimmune diseases.

Prostaglandin Analogues, Phosphodiesterase Inhibitors Effective in Vitiligo as Monotherapy or Add-On Modalities

42 studies with 1027 cases evaluated drugs like bimatoprost and apremilast for vitiligo.

Oral Silymarin Plus Hair Follicle Transplantation Efficacious in Refractory Vitiligo

The study showed significant improvement in repigmentation with silymarin, with patients of different sexes benefiting equally, though monthly differences were not significant.

Exploring Afamelanotide for Vitiligo: Insights into the CUV 105 Phase 3 Clinical Trial

The study is actively recruiting participants at multiple sites across the US.

Monobenzone May Heighten Oxidative Stress and Systemic Health Concerns, Study Suggests

Researchers found that MBEHQ treatment increased oxidative stress and proinflammatory cytokines IL-1β and IL-18 in patients with vitiligo.

Advances in Vitiligo Treatment Focus on Immunomodulatory Pathways, Cellular Grafting, and Emerging Drug Targets

A review examined how vitiligo treatments aim to restore melanocyte function through grafting, phototherapy, immune regulation, antioxidants, and stem cell research.

Understanding the Role of Micronutrients in Vitiligo

Studies show conflicting serum levels of zinc and copper in vitiligo patients, indicating a need for further research.

VYN201 for Vitiligo: Phase 1b Study Confirms Safety

VYNE Therapies announces that aNSV patients saw disease improvement without serious adverse effects.

Study Underscores Safety and Efficacy of Baricitinib with NB-UVB in Vitiligo

Researchers stated the dual-action therapy could offer a promising approach to treat progressive non-segmental vitiligo.

Regenerative Medicine Proves to Be Effective for Vitiligo Treatment

Regenerative methods such as cell therapy and platelet-rich plasma showed promising results in patient repigmentation.

Clinical Characteristics and Management of Late-Onset Vitiligo

LOV has unique clinical traits, epidemiology, and treatment responses compared to early-onset vitiligo, underscoring the need for a tailored management approach.

Excimer Light and Erbium Laser: A Dual Solution for Vitiligo

Researchers emphasized the need for future studies to refine protocols and address economic barriers to combination therapy.

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