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Los Angeles - Laser pretreatment dramatically increases the transdermal delivery of the chemotherapeutic agent 5-FU, according to Dr. Kuo-Hsien Wang, M.D. who presented at the Society for Investigative Dermatology annual meeting. "This method has potential for the treatment of cutaneous malignant diseases and precancerous lesions, such as actinic keratosis, Bowen's disease, and superficial basal cell carcinoma," he said.