PRP Popular for Periorbital Region

A recent study in the Journal of Cosmetic Dermatology announced the results of a literature review conducted to evaluate commonly used non-surgical and minimally invasive treatments for periorbital rejuvenation reports Dermatology Times in a recent article.

Searching published clinical trials and scientific reviews concerning periorbital rejuvenation in the MEDLINE and PubMed databases, the researchers found that autologous PRP is increasingly being used in aesthetic medicine for both skin and hair conditions and is seeing a quick growth in popularity as a modality to achieve skin rejuvenation.

“The mechanism by which PRP leads to skin rejuvenation is by increasing the dermal fibroblast proliferation, expression of matrix metalloproteinase, and collagen synthesis,” write the authors. “The ideal platelet concentration is 2-4 times over baseline, and with a concentration in this range, the highest secretion of endogenous hyaluronic acid was described for skin fibroblasts. These actions can have a positive effect on skin quality and may contribute to a decrease in visible signs of skin aging.”

PRP is a standard treatment option for hair loss, but the authors note that more studies need to be done to assess the cosmetic skin effects of using PRP.

The authors also discuss other treatment options that are used to treat the periorbital area with success, including chemical peels for pigmentation and wrinkles; non-ablative lasers (intense pulsed light, pulse dye, ND:YAG 1320nm, Nd:YAG 1064 nm and Erbium glass 1540) for eyelid tightening, improved skin flexibility and reduction in dark spots; neurotoxins for wrinkles; and fillers for the tear trough region.