Reflecting On 10 Years of Atopic Dermatitis Research

Researchers Peter Arkwright, MBBS, D Phil, FRCPCH, consultant at the Lydia Becker Institute of Immunology and Inflammation at University of Manchester in Manchester, United Kingdom; and Jennifer Koplin, PhD, epidemiologist at the Department of Population Allergy at Murdoch Children's Research Institute in Melbourne, Australia; reviewed a decade of atopic dermatitis (AD) research.

They found 14,406 peer-reviewed publications on AD were listed on PubMed over the last 10 years. Research in the last decade makes up 46% of all AD publications since the first articles were listed over 70 years ago in 1948.¹

As we approach National Eczema Week from September 9-16 and National Eczema Month in October, we’re walking through Arkwright and Koplin’s findings.

References

1. Arkwright PD, Koplin JJ. Impact of a Decade of Research Into Atopic Dermatitis. J Allergy Clin Immunol Pract. 2023;11(1):63-71. doi:10.1016/j.jaip.2022.09.021

2. Simpson EL, Chalmers JR, Hanifin JM, et al. Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. J Allergy Clin Immunol. 2014;134(4):818-823. doi:10.1016/j.jaci.2014.08.005

3. Skjerven HO, Rehbinder EM, Vettukattil R, et al. Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial [published correction appears in Lancet. 2020 Mar 21;395(10228):e53]. Lancet. 2020;395(10228):951-961. doi:10.1016/S0140-6736(19)32983-6

4. Jiang W, Ni B, Liu Z, et al. The Role of Probiotics in the Prevention and Treatment of Atopic Dermatitis in Children: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. Paediatr Drugs. 2020;22(5):535-549. doi:10.1007/s40272-020-00410-6

5. Szajewska H, Horvath A. Lactobacillus rhamnosus GG in the Primary Prevention of Eczema in Children: A Systematic Review and Meta-Analysis. Nutrients. 2018;10(9):1319. Published 2018 Sep 18. doi:10.3390/nu10091319

6. Lin B, Dai R, Lu L, Fan X, Yu Y. Breastfeeding and Atopic Dermatitis Risk: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. Dermatology. 2020;236(4):345-360. doi:10.1159/000503781

7. Güngör D, Nadaud P, LaPergola CC, et al. Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the life span: a systematic review [published correction appears in Am J Clin Nutr. 2019 Oct 1;110(4):1041]. Am J Clin Nutr. 2019;109(Suppl_7):772S-799S. doi:10.1093/ajcn/nqy283

8. Abuabara K, Nicholls SG, Langan SM, et al. Priority research questions in atopic dermatitis: an International Eczema Council eDelphi consensus. Br J Dermatol. 2021;185(1):203-205. doi:10.1111/bjd.19874

9. Williams HC, Schmitt J, Thomas KS, et al. The HOME Core outcome set for clinical trials of atopic dermatitis. J Allergy Clin Immunol. 2022;149(6):1899-1911. doi:10.1016/j.jaci.2022.03.017