Stephanie Manson Brown, MD, MBBS, MRCS: Allergan Aesthetics' Science of Aging and the Future of Aesthetic Medicine

Stephanie Manson Brown, MD, MBBS, MRCS, vice president of R&D and head of Clinical Development and Scientific Innovation at Allergan Aesthetics, recently delved into the Science of Aging program.

This initiative aims to bridge the gap between aging science and aesthetic medicine, shifting the conversation from "anti-aging" to "pro-longevity." By focusing on the underlying biological processes that contribute to aging, such as cellular senescence and oxidative stress, the program explores treatments that not only enhance appearance but also promote overall skin health and longevity.

Manson Brown also shared insights on how the Science of Aging program provides a platform for collaboration between researchers, dermatologists, and aesthetic physicians.

Stephanie Manson Brown, MD, MBBS, MRCS | Image Credit: © Rejuvenation Resource

Q&A

Q: Can you explain how the Science of Aging program integrates with the broader scope of aesthetic medicine? How has it contributed to shifting the mindset from "anti-aging" to "pro-longevity" in clinical practice?

A: Scientific developments in the field of aging can translate into meaningful action in the future of aesthetic medicine. The Science of Aging platform, initiated by Allergan Aesthetics, brings discoveries from aging and longevity science to aesthetic medicine. The program is an educational forum for conversations that break new ground for the field, open a runway to explore novel targets for unmet patient needs, and drive the future blueprint for aesthetics medicine. By continuing to facilitate discussion among top researchers, physicians, and other innovators, we can explore cutting edge science and evolve the collective approach to aging, shifting focus from lifespan to health span (e.g., the number of years lived in good health). We are still in the early days, but the opportunity to harness science and change perceptions around aging is immense, and moving away from a mindset of ‘anti-aging’ is the future.

Q: What recent discoveries in aging mechanisms do you find most promising for future aesthetic treatments?

A: Longevity science is an interdisciplinary field focused on understanding the biological processes and underlying causes of aging and potentially how to slow them down to improve health span. Across the field, research continues to advance rapidly, particularly in the last few years. Research on longevity addresses skin-related changes by exploring the fundamental biological processes that contribute to skin aging, such as cellular senescence, stem cell exhaustion, and oxidative stress. By understanding and working to mitigate these processes, as well as leveraging the power of AI and advanced digital technology, we have the potential to improve skin aging and overall health. I’m a strong believer that investing in skin health is an important part of a holistic approach to pursuing good health. Evolving approaches are fueling future aesthetic interventions that address the root causes of aging – not just the signs and symptoms.

Q: How can these insights shape the daily practices of dermatologists and aesthetic physicians?

A: Trends and innovations affecting how we age have great impact on practitioners and their patients. Treatment strategies such as promoting cellular rejuvenation, enhancing skin barrier function, and protecting against oxidative damage through antioxidants, are integral to addressing aging processes. A targeted aesthetic treatment can do more than improve appearance – it can also help optimize skin function, identify aging factors, target cell regeneration, repair collagen, or enrich structural elements beyond the treatment itself. Improving the skin’s health with the right aesthetic treatments can increase overall longevity while keeping the skin healthier longer.

Q: How does the Science of Aging program contribute to educating dermatologists and aesthetic physicians on the latest research findings?

A: Science of Aging provides a forum for researchers to share their latest innovations in aging and longevity with dermatologists, aesthetic physicians, and others who are on the frontlines of treating patients. Since 2019, Science of Aging has conducted nearly 10 global events, involving dozens of speakers, start-ups, and passionate professionals. We believe that Science of Aging is an integral part of the continuing medical education ecosystem that exists today, offering comprehensive, patient-centric scientific exchange, and educational outreach, all of which can drive awareness and collaboration to help practitioners grow – and patient outcomes improve.

Q: How do you envision the future of aesthetics education evolving, particularly in terms of physician training on pro-longevity strategies? What role do programs like Science of Aging play in preparing physicians for the next generation of aesthetic treatments?

A: Given the rapidly evolving nature of the field of aesthetics, I believe programs like Science of Aging are going play a big role in bringing the latest research and innovation to practicing physicians. At our most recent symposia, for example, discussion topics ranged from exosome innovation, glycobiology, cellular aging mechanisms and genetic medicine to cellular rejuvenation, AI-driven longevity medicine, regenerative immunology, and mRNA therapy. The early science supporting these ideas is promising – and we’re educating physicians to keep them informed as the science continues to evolve.