Study Reveals Botanical Blend Zeropollution is Capable of Shielding Skin From Adverse Effects of Pollution

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Monteloeder, S.L., a subsidiary of SuanNutra, announced today positive data from a study exploring the ability of the company's botanical blend Zeropollution to protect the skin from the negative effects of city pollution and free radical damage on a cellular level.¹

Zeropollution is formulated with a blend of botanical extracts including lemon verbena, rosemary, olive, and Japanese pagoda tree. The lemon verbena extract has been standardized to several active compounds known for their antioxidant and anti-inflammatory properties. These compounds include hydroxytyrosol, verbascoside, and quercetin.

In a recent study led by Laurent Peno-Mazzarino and published in the Journal of Current Issues in Molecular Biology,² Zeropollution demonstrated remarkable efficacy in protecting the skin from the detrimental effects of pollutants.

Ex vivo human skin explants and in vitro models exposed to pollutants such as heavy metals and urban dust particles showed significant improvements in skin barrier function and reduction in oxidative stress.

The study revealed several key mechanisms by which Zeropollution exerts its protective effects. The formula effectively inhibited lipid peroxidation induced by pollutants, while also suppressing inflammatory responses and reducing the production of reactive oxygen species.

Furthermore, Zeropollution demonstrated the ability to counteract the overactivation of the aryl hydrocarbon receptor, a biological pathway implicated in pollutant-induced inflammation and skin damage.

"This study underscores its beneficial effects on guarding the skin from pollution as supported by in vitro models," said Nuria Caturla, PhD, chief R&D officer for Monteloeder, in a news release.¹ "While results of previous clinical studies endorsed Zeropollution's antioxidant and anti-aging effects, this preclinical research delves deeper into the botanical compound's molecular mechanisms."

Zeropollution is available in various delivery formats, ranging from "shots" and soft gels to capsules and effervescent tablets.

In another prior clinical trial, investigators found that supplementation with Zeropollution in 100 women living in heavily-polluted urban areas led to increased skin elasticity and firmness, strengthened skin barrier function, antioxidant status, and overall skin radiance.³

"Zeropollution possesses profound antioxidant and protective properties, as proven by its ability to reduce free-radical damage, inflammation and lipid peroxidation, while also offering protection against heavy metals," Caturla said.¹ "The botanical blend was uniquely crafted to fortify the skin's natural defences against external insults and nourish it from within. This study unveils Zeropollution's antioxidant potential beyond skin health, suggesting cardiopulmonary and endothelial benefits. This broadens its application spectrum beyond nutricosmetics and aligns with the consumer belief that help for a beautiful complexion can emanate from the inside."

References

1. Study illustrates Zeropollution's enhancing skin's resilience to environmental damage. News release. PR Newswire. March 5, 2024. Accessed March 5, 2024. https://www.prnewswire.com/news-releases/study-illustrates-zeropollutions-enhancing-skins-resilience-to-environmental-damage-302079778.html
2. Peno-Mazzarino L, Radionov N, Merino M, et al. Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical Study. Curr Issues Mol Biol. 2024;46(2):1530-1555. Published February 15, 2024. Accessed March 5, 2024. doi:10.3390/cimb46020099
3. Nobile V, Schiano I, Peral A, Giardina S, Spartà E, Caturla N. Antioxidant and reduced skin-ageing effects of a polyphenol-enriched dietary supplement in response to air pollution: a randomized, double-blind, placebo-controlled study. Food Nutr Res. 2021;65:10.29219/fnr.v65.5619. Published March 29, 2021. Accessed March 5, 2024. doi:10.29219/fnr.v65.5619