The Weekly Roundup: August 12-16

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Navigating a Long-Term Journey: From Topicals to Systemic Therapies in AD

Kristine Kucera, MPAS, PA-C, DHS, discusses her patient's challenging atopic dermatitis that was eventually cleared with upadacitinib.

Insights Into Positive Decision for Galderma's RelabotulinumtoxinA in Europe

Sachin Shridharani, MD, FACS, discusses the READY-1 and READY-2 clinical trials and positive support for Relfydess.

Q&A: Study Highlights KT-474's Effectiveness in Targeting IRAK4 for Hidradenitis Suppurativa and Other Inflammatory Diseases

Jared Gollob, MD, shares highlights of Kymera Therapeutics' recent JID publication.

Journal Digest: August 12

This week’s collection of the latest dermatologic studies includes the impact of isotretinoin treatment on femoral cartilage thickness, cystic fibrosis dermatitis arthritis syndrome, the role of intratumoral therapies for cutaneous melanoma, and fractional pigment toning for treating benign epidermal pigmented lesions.

Understanding Dermatological Needs of Gender-Diverse Patients

A recent Australian study reviewed appropriate terminology, gender affirming options, and dermatological considerations in caring for gender-diverse patients.

Neoadjuvant and Adjuvant Vismodegib for Complex Basal Cell Carcinomas

To improve overall outcomes for patients with large basal cell carcinomas, it has been beneficial to employ the use of vismodegib as a neoadjuvant and/or adjuvant treatment.

FDA Approves Nemolizumab for the Treatment of Prurigo Nodularis

Galderma’s nemolizumab is the first approved monoclonal antibody specifically inhibiting the signaling of IL-31.

Chesahna Kindred, MD, MBA, FAAD: Expert Insights on Enhancing Dermatological Care for Patients with Skin of Color

Kindred spoke with Dermatology Times to discuss AbbVie's recent Science of Skin event and improving access to equitable dermatological care.

Study Links Genetic Markers in Rheumatoid Arthritis and Rosacea

The study found 277 differentially expressed genes shared by RA and rosacea, opening up opportunities for treatment research.

Understanding the Patient and Advocate Experience: Psoriatic Disease and Skin of Color

Brenda Kong-Tunac, a patient with PsO, PsA, and skin of color, shares her experiences.

“My Skin My Story” Provides Creative Outlet for Young Patients With Eczema

John Browning, MD, FAAD, FAAP, MBA, discusses the new online platform that allows young patients to share their skin journey with others.

Study Emphasizes Itch Assessment in PsO and AD Trials

Researchers suggested that itch control is key in reducing disease burden and improving life quality for patients with psoriasis and atopic dermatitis.

Verrica Announces Positive Preliminary Topline Results From Part 2 of Phase 2 Study of VP-315 for BCC

The overall reduction of tumor size in all lesions treated in part 2 was approximately 86%.

Izokibep Reaches Key Efficacy Endpoints in Phase 3 HS Trial

The trial revealed that 40% of patients on izokibep achieved HiSCR75 by week 16, a notable improvement over the 20% on placebo.

Insights Into the Approval of Denileukin Diftitox-cxdl for Cutaneous T-Cell Lymphoma

Myron Czuczman, MD, of Citius Pharmaceuticals recently shared perspectives on the role and potential of Lymphir in CTCL.

FDA Clears Candela's Matrix Radiofrequency Platform for Treatment of Facial Wrinkles

The new indication adds to existing clearances for hemostasis and electrocoagulation.

Study Shows AI Offers Mixed Results in Mohs Education

Despite high accuracy scores, the study found AI models often produce overly complex explanations, making them less effective for patient education.

Tailoring Aesthetic Treatments for Patients With Skin of Color

Omer Ibrahim, MD, discusses the nuances of aesthetic procedures for patients with skin of color and the importance of tailored treatments, safety, and improved clinician education.

AI Scribes: Reducing Documentation Time and Uncovering New Ethical Challenges in Health Care

Since the first electronic medical record emerged in 1972, clinicians have found themselves increasingly trapped behind screens.

Hair-Raising Challenges

Zoe Draelos, MD, presents vignettes based on common hair problems that patients face, with possible dermatologic solutions.

Highlights From Illinois Society for Dermatology Physician Assistants Conference

Renata Block, MMS, PA-C, interviews fellow colleagues to discuss conference highlights, Psoriasis Awareness Month, community advocacy, and more.

Increasing Levels of Physical Activity Led to Improvements in Wellbeing, Psychological Health in Patients With Psoriasis

Patients showed significant improvements in skin severity, quality of life, blood pressure, and cardiovascular health, with enhanced psychological well-being.

Is OX40 Inhibition the Next Game Changer for Atopic Dermatitis?

Learn more about the OX40-OX40L pathway and 2 drugs heading toward phase 3 trials.

Comparing Energy-Based Devices for Acne

Although EBDs provided improvements over controls, they did not match the sebum reduction levels achieved by isotretinoin or hormonal therapies.

Approvals Expand Treatment Options

“This approval reflects our dedication to ensuring high-quality treatments are universally accessible,” Claire D’Abreu-Hayling, chief scientific officer of Sandoz, said in a news release.

Topical Tranexamic Acid Does Not Produce Notable Benefits in Macular Amyloidosis

The use of microneedling, however, resulted in decreases in pigmentation and pruritus.

History of Smoking May Correlate With Rosacea Risk, Study Poses

Mendelian randomization suggested a potential causal relationship between the 2 variables.

Study Investigates BTX Dosage for Rosacea Treatment

The study found that higher doses of BTX “significantly” improved facial erythema and patient quality of life compared to lower doses.

Insights From In Vitro Skin Models to Enhance Patient Care

Explore recent research in in vitro complex skin models to study skin homeostasis, aging, and skin disease.