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Immunomodulatory antibodies for melanoma treatment prove promising
July 1st 2011Novel immunomodulatory antibodies such as ipilimumab (Bristol-Myers Squibb) and other experimental treatment options such as melanoma vaccines, chemotherapy agents (Abraxane, Celgene) and targeted drug therapies (BRAF inhibitors) are proving effective in the treatment of patients with late-stage melanoma, offering increased hope in the continuing battle against this deadly skin cancer.
How would accountable care organizations impact dermatology?
July 1st 2011In my last editorial, I expressed mystification about what exactly was being "reformed" by the passage of the 2,700-page "Patient Protection and Affordable Care Act." Finally, a limited number of details about the provisions of this act are finally coming to light. The latest is the Accountable Care Organizations (ACOs), which represents one of the first proposals to provide initiatives to reform healthcare delivery.
Lawmaker says Capitol Hill aims to tackle Medicare reimbursement challenges soon
July 1st 2011The fact that Medicare reform is being debated on Capitol Hill and a near 30 percent Medicare physician pay cut looms in January appears to be moving some influential lawmakers to get serious about reforming the system used to pay Medicare doctors. House Energy and Commerce Committee Chairman Fred Upton (R-Mich.) has said a solution is "on the short list of things getting done this summer," and two hearings were held in May as part of that process.
Ablative fractional laser resurfacing associated with pseudomelanoma
July 1st 2011The occurrence of several cases of pseudomelanoma after ablative fractional CO2 laser resurfacing underscore the importance of careful pre- and postoperative evaluation to avoid misdiagnosing a benign lesion as malignant melanoma, says Deborah Sarnoff, M.D.
Topically applied neurotoxin addresses wrinkles without needles
July 1st 2011A groundbreaking topically applied neurotoxin now in phase 2 trials would provide a painless, injection-free wrinkle-relaxing alternative if it is eventually approved by regulators, investigators say. "The product is being developed by Revance and would offer an additional choice for the clinician and the patient," says Michael A.C. Kane, M.D., of Kane Plastic Surgery, New York, and an investigator with the trial. "Many people are needle-phobic and would probably prefer a topical over an injection."
New botulinum toxin expected to challenge cosmetic market leaders
July 1st 2011The safety and dose equivalency of PurTox (Mentor) should place the botulinum toxin head-to-head with Botox when it reaches the U.S. market, according to a European physician who has experience using the pure toxin there. The newcomer, PurTox, is said to be equivalent to the universal comparator Botox (onabotulinumtoxinA, Allergan) in terms of dosing, and, therefore, represents a potential future nemesis for Botox and other toxins on the market.
Biofilms from dermal fillers management with proper course of action
July 1st 2011Experts believe many side effects of fillers are caused by biofilms, but these infections are difficult to document because biofilms are hard to culture, says Rhoda Narins, M.D., of the Dermatology Surgery & Laser Center, New York, and clinical professor of dermatology, New York University Medical Center, New York. Once a biofilm is suspected, however, choosing the right course of action is critical in effectively managing the condition.
Xeomin expected to drive down botulinum toxin prices when it reaches market
July 1st 2011When it enters the U.S. market, Xeomin is expected to have a unit-to-unit equivalence to Botox, the standard ?sthetic toxin in dermatology practices for years. Current off-label use hasn't shown any particular clinical advantage for Xeomin (incobotulinumtoxinA, Merz) over Botox (onabotulinumtoxinA, Allergan) or Dysport (abobotulinumtoxinA, Medicis), but the new toxin will broaden clinicians' ?sthetic options and may spur price competition in the U.S.
Proper diagnosis of nonhealing wounds crucial to successful treatment
July 1st 2011Treating nonhealing wounds with advanced therapies requires knowing exactly what you're treating. For example, when considering engineered tissue products for wound healing, "As always, we want to treat the cause of the wound, prepare the wound bed and treat patient-centered concerns," says Severin Laeuchli, M.D., a dermatologist with the University of Zurich's department of dermatology.
Study of cosmetic dermatology patient demographics yields surprising results
July 1st 2011Educated, married, mothers, women who are older than their husbands - that's not necessarily the image of the typical cosmetic surgery patient, but a couple of chance comments from patients led three generations of a family of researchers to combine forces to create a prospective study of cosmetic patients that yielded interesting, and unexpected, results.
Novel agent boosts survival in metastatic melanoma patients
July 1st 2011An investigational melanoma drug that targets a mutation found in about half of tumors reduces the risk of progression in patients with advanced disease by nearly three-fourths, and cuts the risk of dying by 63 percent, new research shows.