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San Diego - Results from a U.S. Food and Drug Administration pivotal trial demonstrate that the injectable wrinkle filler Artecoll, composed of polymethylmethacralate (PMMA) microspheres (20 percent) suspended in an ultra-purified collagen carrier (80 percent) is an equally safe, but longer-lasting, alternative to bovine collagen for the cosmetic correction of a variety of facial contour defects, Steven R. Cohen, M.D., tells Dermatology Times.